Ctrl Alt Del - Tragically l337 is about two guys playing video games. One of them, Ethan, does all these insane things like beating up a game company executive, declaring a holiday season (winter-een-mas), blow up the PC, and so on. The other guy ends up 'cleaning the mess'. Later a linux geek with a pet penguin and a 'gaming girl' join the group. Ethan even creates an intelligent robot out of his Xbox which also becomes part of the group. This is my favorite comic strip.
VG Cats (video gaming cats) is also about video games but more focused on them than Ctrl Alt Del.
Everyone knows Dilbert and reads it religiously right?
Sinfest - uncompromising originality.
And the classic: Garfield.
UPDATE:
Terrible mistake: I forgot userfriendly.
